ABSTRACT
BACKGROUND AND OBJECTIVE: There is a common progression known as the allergic march from atopic dermatitis to allergic asthma. There are many risk factors affecting allergic march such as expanded exposure to multi-allergens, family history of atopy and other environmental factors etc. In this study, we tried to check PEFR in atopic dermatitis children before development of asthma and to determine whether the PEFR can be a predicting factor of asthma. METHODS: Nineteen atopic dermatitis children(group A), 21 atopic dermatitis children with asthma(group B) and 25 control children were enrolled in this study. We checked the PEFR in each subject and calculated the % predicted value. We compared the value of PEFR in each group. RESULTS: Males were predominant in all study groups and the mean ages of the subjects were 5.9 years in group A, 6.8 years in group B, and 8.7 years in control group. The % predicted values of PEFR were 86.57+/-7.32 in group A, 88.16+/-10.33 in group B, and 100.68+/-17.56 in control group. There was a significant difference of PEFR between group A and control group. Additionally, the PEFR in house dust mite sensitive group was lower than that of house dust mite allergen insensitive group among atopic dermatitis group. CONCLUSION: The lower value of PEFR in atopic dermatitis group suggests that there is some degree of pulmonary obstruction, even if bronchial asthma does not occur. Therefore, the PEFR of atopic dermatitis can be a predicting factor for the development of asthma.
Subject(s)
Child , Humans , Male , Asthma , Dermatitis, Atopic , Peak Expiratory Flow Rate , Pyroglyphidae , Risk FactorsABSTRACT
The authors report a 7-year-old boy with neuroblastoma complicated by severe hypertension and pulmonary edema. Abdominal computed tomographic scan revealed a huge mass surrounding the aorta. After administration of cancer treatment, there was a marked increase in serum catecholamines level and hypertension, which resulted in pulmonary edema and heart failure. Alpha adrenergic blocking agents (prazocin, terazocin) were administrated, successfully controlling the hypertension. The tumor differentiated to ganglioneuroblastoma after chemotherapy. The catecholamine production of the residual neuroblastoma must have increased because the treatment induced differentiation. It is important to watch for the development of hypertension during the treatment of neuroblastoma.
Subject(s)
Child , Humans , Male , Adrenergic alpha-Antagonists , Aorta , Catecholamines , Drug Therapy , Ganglioneuroblastoma , Heart Failure , Hypertension , Neuroblastoma , Pulmonary EdemaABSTRACT
Monosomy 7 syndrome is a rare myeloproliferative disorder of children, and has a clinical presentation similar to JCML. Both syndromes present in children younger than 2 years of age. Pallor, lymphaenopathy, hepatosplenomegaly, recurrent infection, facial rash and petechial bleeding are frequently present. The hematologic picture is characterized by leukocytosis with monocytosis, anemia, thrombocytopenia. It is important to distinguish these two disorders because of their different natural courses. The course of JCML is brief, with most patients dying within 9 months. Patients with monosomy 7 syndrome often present initially with repeated bacterial infections and develop AML after a latent period of 3~6 years. We report a case of monosomy 7 syndrome with typical clinical course in a 3-year-old male patient. The patient experienced a malignant transformation into AML. To our knowledge, this is the first case report of malignant transformation in monosomy 7 syndrome of children in Korea.